Cancer Discovery (2013)

A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

Science Translational Medicine (2011)

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.

Science Translational Medicine (2011)

Discovery and preclinical validation of drug indications using compendia of public gene expression data.

Briefings in Bioinformatics (2011)

Exploiting drug–disease relationships for computational drug repositioning.

Journal of Cardiovascular Translational Research (2010)

Drug discovery in a multidimensional world: systems, patterns, and networks.

Gastroenterology (2010)

Biomarker and drug discovery for gastroenterology through translational bioinformatics.

PLoS Computational Biology (2010)

Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets.

Nature Methods (2010)

Cell type-specific gene expression differences in complex tissues.

Molecular Systems Biology (2009)

Disease signatures are robust across tissues and experiments.

Clinical Pharmacology and Therapeutics (2009)

Systematic evaluation of drug-disease relationships to identify leads for novel drug uses.

Nature Methods (2007)

AILUN: reannotating gene expression data automatically.

Nature Reviews Drug Discovery (2009)

A network view of disease and compound screening.

Pharmacogenomics (2009)

Integrative genomics and drug development.

Nature Biotechnology (2006)

Creation and implications of a phenome-genome network.